NDLI: Oxidative stress elevated DNA damage and homocysteine level in normal pregnant women in a segment of Pakistani population

Content Provider	Springer Nature Link
Author	Bukhari, Shazia A. Rajoka, Muhammad Ibrahim Ibrahim, Z. Jalal, Fatima Rana, Shahid Mahboob Nagra, Saeed A.
Copyright Year	2010
Abstract	Maternal oxidative stress during pregnancy may impair fetal growth and help in the development of diseases in adulthood. The aim of current study was to assess total oxidation status (TOS), related parameters and their relationship to DNA damage (%) and homocysteine level in normal pregnant women in low-income participants. In a cross-sectional study healthy women were grouped as normal, while age matched nulliparous and singleton pregnancies were included for first, second and third trimester groups. TOS (P < 0.01), melanodialdehyde (MDA) (P < 0.001), aspartate aminotransferase (AST) (P < 0.01), triiodothyronine (T3) (P < 0.01), thyroxine (T4) (P < 0.01), and homocysteine (P < 0.001), in pregnant women were significantly higher as compared to normal healthy women. While serum total proteins (P < 0.01), albumin (P < 0.01) and total antioxidant status (TAS) (P < 0.001) decreased significantly as compared to normal healthy women. Women in third trimester showed a significantly high level of body temperature (P < 0.01), triglyceride (P < 0.01), LDL-cholesterol (P < 0.05), AST (P < 0.01), T3 (P < 0.01), homocysteine (P < 0.001), TOS (P < 0.01) and MDA (P < 0.001) but a lower concentration of serum proteins, albumin and TAS at the end of the pregnancy. Pearson correlation indicated a positive relationship of homocysteine with triglycerides (P < 0.027), TOS (P < 0.01), MDA (P < 0.035) and had a negative relationship with total protein (P < 0.026). DNA damage was strongly related with T3 (P < 0.008), TOS (P < 0.02), MDA (P < 0.037) and MBI (P < 0.048) profiles of pregnant women. These changes were considered normal for pregnant women having optimum blood pressure and normal child birth. Hormonal influences and hemodilution may contribute towards the observed changes in this study.
Starting Page	2703
Ending Page	2710
Page Count	8
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	38
Issue Number	4
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-11-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pregnancy Biochemical profiles DNA damage Pregnancy markers Pakistan Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Plasma homocysteine and DNA damage profiles in normal and obese subjects in the Pakistani population

Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy

Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats

DNA damage and repair in Fuchs endothelial corneal dystrophy

DNA typing of Pakistani cattle breeds Tharparkar and Red Sindhi by microsatellite markers

Some Biochemical Markers of Oxidative Stress in Pregnant Nigerian Women

The effect of aging on the DNA damage and repair capacity in 2BS cells undergoing oxidative stress

Molecular classification of Pakistani collared dove through DNA barcoding

Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage

Oxidative stress elevated DNA damage and homocysteine level in normal pregnant women in a segment of Pakistani population

Similar Documents

Plasma homocysteine and DNA damage profiles in normal and obese subjects in the Pakistani population

Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy

Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats

DNA damage and repair in Fuchs endothelial corneal dystrophy

DNA typing of Pakistani cattle breeds Tharparkar and Red Sindhi by microsatellite markers

Some Biochemical Markers of Oxidative Stress in Pregnant Nigerian Women

The effect of aging on the DNA damage and repair capacity in 2BS cells undergoing oxidative stress

Molecular classification of Pakistani collared dove through DNA barcoding

Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage

Oxidative stress elevated DNA damage and homocysteine level in normal pregnant women in a segment of Pakistani population