NDLI: Plasma lipids and lipoproteins in children and young adults with major β-thalassemia from western Iran: influence of genotype

Content Provider	Springer Nature Link
Author	Madani, Hamid Rahimi, Zohreh Manavi Shad, Mohammad Mozafari, Hadi Akramipour, Reza Vaisi Raygani, Asad Rezaei, Mansour Malek Khosravi, Shohreh Shakiba, Ebrahim Parsian, Abbas
Copyright Year	2010
Abstract	To determine the plasma lipid and lipoprotein profiles and their possible association with the type of β-thalassemia mutation we studied 103 major β-thalassemia patients including 71 children and 32 young adults compared to 102 healthy subjects consisted of 90 children and 12 young healthy adults. The plasma lipid and lipoprotein levels were measured by conventional methods. Considering all of the patients the levels of total cholesterol (TC), LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C) were significantly lower compared to controls. However, the level of TG was significantly higher in cases than controls. Comparing thalassemic patients homozygous for a β$^{0}$ type of mutation with those homozygous for a β$^{+}$ type of mutation (IVSI.110 G:A) indicated that the levels of LDL-C, TC were significantly increased and TG concentration tended to be higher in the latter patients. In conclusion, our study indicates that hemolytic stress results in hypocholesterolemia in major β-thalassemia patients and the presence of more severe genotype in patients is correlated with more reduction in TG, TC, and LDL-C levels.
Starting Page	2573
Ending Page	2578
Page Count	6
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	38
Issue Number	4
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-11-18
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	β-thalassemia Mutation Lipid Lipoprotein Western Iran Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

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