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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sui, Xinbing Wang, Da Geng, Shumin Zhou, Gongli He, Chao Hu, Xiaotong |
| Copyright Year | 2011 |
| Abstract | Protocadherins are a major subfamily of the cadherin superfamily. Their functions and intracellular signal transduction are poorly understood, although some have been explored in nervous system development. However, recent researches have shown that protocadherins frequently act as tumor suppressor genes (TSGs) and inactivation of these genes through promoter methylation is closely correlated with tumor development. Furthermore, these methylated protocadherins may serve as tumor biomarkers in various body fluids, stool and scrapings not only for early cancer diagnosis, but also for assessing prognosis and monitoring response to therapy. Thus, methylated promoters of genes encoding protocadherins show promise as a new cancer biomarker family. |
| Starting Page | 1105 |
| Ending Page | 1111 |
| Page Count | 7 |
| File Format | |
| ISSN | 03014851 |
| Journal | Molecular Biology Reports |
| Volume Number | 39 |
| Issue Number | 2 |
| e-ISSN | 15734978 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-05-21 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Methylation Protocadherin Cancer Biomarker Animal Biochemistry Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology |
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