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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhao, Yaping Zhang, Chunmei Chen, Xiaohui Gao, Chunlin Ji, Chenbo Chen, Fukun Zhu, Chun Zhu, Jingai Wang, Jialin Qian, Lingmei Guo, Xirong |
| Copyright Year | 2010 |
| Abstract | NYGGF4 is a recently discovered gene that is involved in obesity-associated insulin resistance. The exact mechanism by which NYGGF4 induces insulin resistance has not yet been fully elucidated. In this study, we demonstrated that the overexpression of NYGGF4 in 3T3-L1 adipocytes decreased mitochondrial mass, mitochondrial DNA, and intracellular ATP synthesis. In addition, NYGGF4 overexpression also led to an imbalance of the mitochondrial dynamics and excess intracellular ROS production. Collectively, our results indicated that the overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance. |
| Starting Page | 41 |
| Ending Page | 48 |
| Page Count | 8 |
| File Format | |
| ISSN | 03008177 |
| Journal | Molecular and Cellular Biochemistry |
| Volume Number | 340 |
| Issue Number | 1-2 |
| e-ISSN | 15734919 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2010-02-18 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Adipocyte Insulin resistance NYGGF4 Mitochondria Cardiology Oncology Medical Biochemistry Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Clinical Biochemistry Molecular Biology |
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