NDLI: Toxic effects of protoberberine alkaloids from Rhizoma Coptidis on Tetrahymena thermophila BF$_{5}$ growth based on microcalorimetry : A reliable evaluation method of structure

Content Provider	Springer Nature Link
Author	Han, Yumei Yan, Dan Zhao, Yanling Peng, Cheng Xiao, Xiaohe
Copyright Year	2011
Abstract	Rhizoma Coptidis consists mainly of protoberberine alkaloids (PAs), and has been used for many years as a traditional medicine. Recent research revealed the toxicity of Rhizoma Coptidis, but studies focusing on the relationships between the structures of PAs and their toxicities are lacking. The toxic effects of four PAs from Rhizoma Coptidis on the growth of Tetrahymena thermophila BF$_{5}$ were investigated by microcalorimetry. The power-time curves of T. thermophila BF$_{5}$ with and without PAs were obtained; the extent and duration of toxic effects on the metabolism of this organism were evaluated by studying thermokinetic parameters and the half-inhibitory ratio (IC $_{50}$). All the thermokinetic parameters showed regular variations with alteration of PA concentrations. The magnitude of the toxic effects of PAs was ascertained from IC $_{50}$ values: palmatine > jateorhizine > berberine ≈ coptisine. The structure–function relationship of PAs indicated that the C2 and C3 positions contributed more to the toxic effect of PAs. That is, when substituted with methoxyl groups, the toxic effect would be increased.
Starting Page	341
Ending Page	346
Page Count	6
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	108
Issue Number	1
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-08-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Protoberberine alkoloid Toxicology Microcalorimetry Tetrahymena thermophila BF$_{5}$ Rhizoma Coptidis Inorganic Chemistry Physical Chemistry Measurement Science and Instrumentation Analytical Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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