NDLI: Thermal behavior and signature patterns of human cytokine and soluble cytokine receptors investigated using dielectric thermal analysis and thermogravimetry

Content Provider	Springer Nature Link
Author	Saleh, Salaam W. More Molek, Susan E. Mantheni, Druthiman Reddy Maheswaram, Manik Pavan Kumar Sam Yellowe, Tobili Riga, Alan T.
Copyright Year	2011
Abstract	Cytokines are small regulatory proteins secreted mostly by cells of the immune system. Cytokines participate in anti-inflammatory and pro-inflammatory processes in the body and in responses to host exposure to pathogens. In this study, the thermal behavior of human recombinant cytokines and soluble cytokine receptors; IFNγ, TNFα, IL-1 receptor antagonist, soluble TNF-receptor types 1 and 2, and sIL-2 receptor α were analyzed by dielectric thermal analysis at 37 °C and by thermogravimetry. Measurements were performed at a frequency range of 0.1–300,000 Hz. Permittivity and loss factor measurements were used to calculate mobility of charges (tan δ values) in the proteins from Debye plots. Peak frequencies and polarization times were used to determine dielectric signatures for each cytokine and receptor. Peak frequencies and polarization times were obtained for each cytokine and receptor analyzed. Detection of unique dielectric signatures of the proteins will aid development of sensitive dielectric sensors capable of detecting cytokines and soluble cytokine receptors in various human samples for malaria diagnosis.
Starting Page	41
Ending Page	51
Page Count	11
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	108
Issue Number	1
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-04-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dielectric thermal analysis Thermogravimatric analysis Cytokines Malaria Plasmodium falciparum Polarization times Inorganic Chemistry Physical Chemistry Measurement Science and Instrumentation Analytical Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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