NDLI: Thermal study of ethyl cellulose coating films used for modified release (MR) dosage forms

Content Provider	Springer Nature Link
Author	Regdon, Géza Hegyesi, Diána Pintye Hódi, Klára
Copyright Year	2011
Abstract	The aim of our research was to investigate the effect of the length of the polymer chain and the concentration of triethyl citrate used as a plasticizer on the thermal stability of the film structure in the case of two ethyl cellulose films (EC 10 and EC 45) used for preparing MR dosage forms. The influence of storage time was studied by monitoring the changes in the thermoanalytical parameters and by performing TG–MS examinations. It was found that the decomposition of the plasticizer from the arising film structure is retarded and a more homogeneous sample, therefore a better film can be prepared from EC 45. Mass spectrography performed as a coupled technique also proved that the films stayed stable until approximately 200 °C. Based on the above results, the composition prepared from EC 45 polymer with 5% triethyl citrate as plasticizer is recommended for making MR dosage forms.
Starting Page	347
Ending Page	352
Page Count	6
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	108
Issue Number	1
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-09-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ethyl cellulose Triethyl citrate Free films Physical–chemical investigations MFT Glass transition temperature DSC TG–MS Inorganic Chemistry Physical Chemistry Measurement Science and Instrumentation Analytical Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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