NDLI: Structural Genomics of Minimal Organisms and Protein Fold Space

Content Provider	Springer Nature Link
Author	Kim, Sung Hou Shin, Dong Hae Liu, Jinyu Oganesyan, Vaheh Chen, Shengfeng Xu, Qian Steven Kim, Jeong Sun Das, Debanu Schulze Gahmen, Ursula Holbrook, Stephen R. Holbrook, Elizabeth L. Martinez, Bru A. Oganesyan, Natalia DeGiovanni, Andy Lou, Yun Henriquez, Marlene Huang, Candice Jancarik, Jaru Pufan, Ramona Choi, In Geol Chandonia, John Marc Hou, Jingtong Gold, Barbara Yokota, Hisao Brenner, Steven E. Adams, Paul D. Kim, Rosalind
Copyright Year	2005
Abstract	The initial aim of the Berkeley Structural Genomics Center is to obtain a near-complete structural complement of two minimal organisms, closely related pathogens Mycoplasma genitalium and M. pneumoniae. The former has fewer than 500 genes and the latter fewer than 700 genes. To achieve this goal, the current protein targets have been selected starting with those predicted to be most tractable and likely to yield new structural and functional information. During the past 3 years, the semi-automated structural genomics pipeline has been set up from cloning, expression, purification, and ultimately to structural determination. The results from the pipeline substantially increased the coverage of the protein fold space of M. pneumoniae and M. genitalium. Furthermore, about 1/2 of the structures of ‘unique’ protein sequences revealed new and novel folds, and over 2/3 of the structures of previously annotated ‘hypothetical proteins’ inferred their molecular functions.
Starting Page	63
Ending Page	70
Page Count	8
File Format	PDF
ISSN	1345711X
Journal	Journal of Structural and Functional Genomics
Volume Number	6
Issue Number	2-3
e-ISSN	15700267
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Berkeley Structural Genomics Center minimal organisms molecular function protein fold space structural genomics Human Genetics Bioinformatics Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Genetics Structural Biology Biochemistry

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