NDLI: Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive $^{131}$I in the cancer cell lines

Content Provider	Springer Nature Link
Author	Uzaras, Cansu Avcıbaşı, Uğur Demiroğlu, Hasan Medine, Emin İlker Kılçar, Ayfer Yurt Müftüler, Fazilet Zümrüt Biber Ünak, Perihan
Copyright Year	2015
Abstract	The aim of this study is to determine the incorporations of PHT radiolabeled with $^{131}$I ($^{131}$I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of $^{131}$I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of $^{131}$I, $^{131}$I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of $^{131}$I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, $^{131}$I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.
Starting Page	131
Ending Page	140
Page Count	10
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	307
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Phenytoin Radiolabeling Epilepsy Diphenylhydantoin U-87 MG Daoy and A549 cancerous cell lines Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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