NDLI: Comparative biological parameters for the evaluation of common renal pharmaceutical preparations: $^{99m}$Tc-DTPA, $^{99m}$Tc-GH, and $^{99m}$Tc-DMSA

Content Provider	Springer Nature Link
Author	Al Azzawi, Hisham M. A. Al Nuzal, Saadi M. D. Badi, Jameel M.
Copyright Year	2015
Abstract	This work is concerned on establishing the necessary comparative quality control biological parameters for the evaluation of locally produced renal pharmaceutical preparations viz. tin complexes of $^{99m}$Tc-DTPA, $^{99m}$Tc-GH, and $^{99m}$Tc-DMSA using gel chromatography column scanning techniques. Radiochemical purity, labeling yields, organ distribution, blood clearance and plasma protein binding were used as a selected indicator for quality control. The higher renal accumulation and tissue distribution were apparent with $^{99m}$Tc-DTPA in mice, while blood retention was considerably low. The blood clearance of $^{99m}$Tc-DMSA was relatively slow, while that of $^{99m}$Tc-GH was rapid. The binding of $^{99m}$Tc-DTPA, $^{99m}$Tc-GH and $^{99m}$Tc-DMSA with plasma protein were found to be 5, 65, and 95 % at 1.0 h, respectively. The stability of these cold kits was not affected on storing at 37 °C for 30 days.
Starting Page	123
Ending Page	130
Page Count	8
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	307
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-05-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Quality control $^{99m}$Tc-DTPA $^{99m}$Tc-GH and $^{99m}$Tc-DMSA renal preparations Radiochemical purity Plasma protein binding Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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