NDLI: Neutral $^{99m}$Tc(CO)$_{3}$ complexes of “clicked” nitroimidazoles for the detection of tumor hypoxia

Content Provider	Springer Nature Link
Author	Bhadwal, Mohini Mallia, Madhava B. Sarma, Haladhar Dev Banerjee, Sharmila
Copyright Year	2015
Abstract	In the present work, three neutral $^{99m}$Tc(CO)$_{3}$ complexes of nitroimidazole were synthesized and their potential to detect tumor hypoxia is evaluated in vivo. Triazole derivatives of 2-, 4- and 5-nitroimidazole were synthesized via ‘click chemistry’ route. The ligands synthesized were characterized and subsequently radiolabeled using [$^{99m}$Tc(CO)$_{3}$(H$_{2}$O)$_{3}$]$^{+}$ precursor complex to obtain corresponding neutral $^{99m}$Tc(CO)$_{3}$ complexes in >90 % radio chemical purity. The complexes were subsequently evaluated in Swiss mice bearing fibrosarcoma tumor and in vivo distribution observed was thoroughly analyzed. All complexes showed uptake in tumor, however, contrary to general expectations, the 5-nitroimidazole complex showed significantly higher tumor uptake (p < 0.05) at 30 min and 60 min p.i., compared to the 2-nitroimidazole counterpart. Though a conclusive explanation for this observation could not be obtained, present study underlined the significance of evaluating nitroimidazole radiotracers other than 2-nitroimidazole for detecting tissue hypoxia.
Starting Page	69
Ending Page	77
Page Count	9
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	307
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-05-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypoxia Nitroimidazole [$^{99m}$Tc(CO)$_{3}$(H$_{2}$O)$_{3}$]$^{+}$ precursor complex Click-chemistry Neutral complexes Biodistribution Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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