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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tekin, Volkan Biber Muftuler, F. Zumrut Yurt Kilcar, Ayfer Unak, Perihan |
| Copyright Year | 2014 |
| Abstract | Lawsonia inermis (henna) is one of the most effective medicinal plants and it has been using for treatment of wounds and burns for centuries. The using of Henna leaves is very popular for cosmetic as well as medicine in many countries. Henna leaves contain lots of different compounds and lawsone (LW) is the main one. In current study, extraction with bidistillated water of henna leaves was performed and LW was isolated by using high performance liquid chromatography system. Chemical structure of LW was evaluated by nuclear magnetic resonance method. LW was radiolabeled with iodine-131 ($^{131}$I) radionuclide which is well known for nuclear imaging and therapy in nuclear medicine by utilizing iodogen method. The yield of radiolabeling of LW ($^{131}$I-LW) was calculated as 92.70 ± 4.312 % (n = 10) by thin layer radio chromatography. Its in vivo biological activity was investigated by biodistribution studies which were performed by using healthy female and male Balb/C mice. According to results of biodistribution, uptake of $^{131}$I labeled LW compound in uterus, breast and ovary for female mice and prostate in male mice was higher than other organs in the body. |
| Starting Page | 225 |
| Ending Page | 232 |
| Page Count | 8 |
| File Format | |
| ISSN | 02365731 |
| Journal | Journal of Radioanalytical and Nuclear Chemistry |
| Volume Number | 302 |
| Issue Number | 1 |
| e-ISSN | 15882780 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-06-08 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Lawsonia inermis (henna) leaves extract Lawsone Radioiodination $^{131}$I Biodistribution Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering |
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