NDLI: Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods

Content Provider	Springer Nature Link
Author	Tekin, Volkan Biber Muftuler, F. Zumrut Kozgus Guldu, Ozge Yurt Kilcar, Ayfer Medine, E. Ilker Yavuz, Murat Unak, Perihan Timur, Suna
Copyright Year	2014
Abstract	WST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 µg/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW ($^{131}$I-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, $^{131}$I-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.
Starting Page	701
Ending Page	708
Page Count	8
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	303
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-08-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lawsonia inermis Lawsone $^{131}$I Cell culture Wound healing Antibacterial and antifungal activity Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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