NDLI: Vanillin Phosphorescence as a Probe of Molecular Mobility in Amorphous Sucrose

Content Provider	Springer Nature Link
Author	Tiwari, Rashmi S. Ludescher, Richard D.
Copyright Year	2009
Abstract	Changes in molecular mobility are important in defining the stability and quality of amorphous solid foods, pharmaceuticals, and other solid biomaterials. Predictions of stability must consider matrix mobility below and above T$_{g}$ (the glass transition temperature); measurement of molecular mobility in amorphous solids over time scales ranging from <10$^{−9}$ s to >10$^{8}$ s requires specialized methods. This research investigated how the steady-state and time-resolved emission and intensity of phosphorescence from vanillin (4-hydroxy-3-methoxy benzaldehyde), a common flavor compound, can be used to probe molecular mobility when dispersed within amorphous pure sucrose films. Phosphorescence emission spectra and time-resolved intensity decays, measured in sucrose as a function of temperature in the absence of oxygen, were strongly modulated by matrix molecular mobility. Temperature had a significant effect on vanillin phosphorescence peak frequency and bandwidth, intensity, and lifetime both in the glass and in the melt. Time-resolved phosphorescence intensity decays from vanillin were multiexponential both below and above the glass transition temperature, indicating that the pure (single component) amorphous matrix was dynamically heterogeneous on the molecular level. These data show that vanillin is a promising intrinsic probe of molecular mobility and dynamic heterogeneity in amorphous solid foods and perhaps pharmaceuticals.
Starting Page	125
Ending Page	133
Page Count	9
File Format	PDF
ISSN	10530509
Journal	Journal of Fluorescence
Volume Number	20
Issue Number	1
e-ISSN	15734994
Language	English
Publisher	Springer US
Publisher Date	2009-08-21
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	4-hydroxy-3-methoxy benzaldehyde Room temperature phosphorescence Amorphous sugar glass Glass transition Analytical Chemistry Biochemistry Biotechnology Biophysics and Biological Physics Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Sociology and Political Science Spectroscopy Law Biochemistry Clinical Biochemistry Clinical Psychology

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