NDLI: The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy

Content Provider	Springer Nature Link
Author	Lani, Athina Kourkoumelis, Nikolaos Baliouskas, Gerasimos Tzaphlidou, Margaret
Copyright Year	2014
Abstract	Fourier transform infrared spectroscopy is utilized to examine the effects of increased calcium, vitamin D, and combined calcium-vitamin D supplementation on osteoporotic rabbit bones with induced inflammation. The study includes different bone sites (femur, tibia, humerus, vertebral rib) in an effort to explore possible differences among the sites. We evaluate the following parameters: mineral-to-matrix ratio, carbonate content, and non-apatitic species (labile acid phosphate and labile carbonate) contribution to bone mineral. Results show that a relatively high dose of calcium or calcium with vitamin D supplementation increases the bone mineralization index significantly. On the other hand, vitamin D alone is not as effective in promoting mineralization even with high intake. Mature B-type apatite was detected for the group with calcium supplementation similar to that of aged bone. High vitamin D intake led to increased labile species concentration revealing bone formation. This is directly associated with the suppression of pro-inflammatory cytokines linked to induced inflammation. The latter is known to adversely alter bone metabolism, contributing to the aetiopathogenesis of osteoporosis. Thus, a high intake of vitamin D under inflammation-induced osteoporosis does not promote mineralization but suppresses bone resorption and restores metabolic balance.
Starting Page	401
Ending Page	412
Page Count	12
File Format	PDF
ISSN	00920606
Journal	Journal of Biological Physics
Volume Number	40
Issue Number	4
e-ISSN	15730689
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-07-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	FTIR spectroscopy Calcium Vitamin D Induced inflammation Osteoporosis Bone composition Biophysics and Biological Physics Biochemistry Statistical Physics, Dynamical Systems and Complexity Neurosciences Soft and Granular Matter, Complex Fluids and Microfluidics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Atomic and Molecular Physics, and Optics Molecular Biology Biophysics

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