NDLI: AFM-based dual nano-mechanical phenotypes for cancer metastasis

Content Provider	Springer Nature Link
Author	Park, Soyeun Lee, Yong J.
Copyright Year	2014
Abstract	An enhanced mechanical compliance is considered to be a mechanical indicator for metastatic cancer cells. Our study using atomic force microscopy (AFM) revealed that breast cancer cells agreed well with this hypothesis. However, prostate cancer cells displayed a reverse correlation; less metastatic prostate cancer cells were more mechanically compliant. Two-dimensional AFM force spectroscopy was performed to characterize dual mechanical properties—the cell–substrate adhesion as well as the mechanical compliance. Interestingly, prostate cancer cells displayed a strong positive correlation between the cell–substrate adhesion and metastatic potential. However, there was no clearly observable correlation between the cell–substrate adhesion and the metastatic potential despite variations in mechanical compliance of breast cancer cells. These results suggest that the correlation between the dual mechanical signatures and metastatic potential be uniquely identified for cancer cells originating from different organs. We postulate that this correlation could reveal which step of cancer progression is favorable in terms of physical interaction between cancer cells and micro-environments. We expect that based on the “seed and soil hypothesis”, the identification of the dual mechanical phenotypes, could provide a new insight for understanding how a dominant metastatic site is determined for cancer cells originating from specific organs.
Starting Page	413
Ending Page	419
Page Count	7
File Format	PDF
ISSN	00920606
Journal	Journal of Biological Physics
Volume Number	40
Issue Number	4
e-ISSN	15730689
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-30
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Atomic force microscopy Force spectroscopy Metastatic potential Mechano-phenotype Cell–substrate adhesion Mechanical compliance Biophysics and Biological Physics Biochemistry Statistical Physics, Dynamical Systems and Complexity Neurosciences Soft and Granular Matter, Complex Fluids and Microfluidics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Atomic and Molecular Physics, and Optics Molecular Biology Biophysics

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