NDLI: Bonding interactions and stability assessment of biopolymer material prepared using type III collagen of avian intestine and anionic polysaccharides

Content Provider	Springer Nature Link
Author	Sailakshmi, G. Mitra, Tapas Gnanamani, A. Kumara Raja, S. Thirupathy Thiruselvi, T. Selvaraj, Naga Vignesh Ramesh, Gopal Mandal, A. B.
Copyright Year	2011
Abstract	The present study demonstrate bonding interactions between anionic polysaccharides, alginic acid (AA) and type III collagen extracted from avian intestine used for the preparation of thermally stable and biodegradable biopolymer material. Further the study describes, optimum conditions (pH, temperature and NaCl concentration) required for the formation of fibrils in type III collagen, assessment on degree of cross-linking, nature of bonding patterns, biocompatibility and biodegradability of the cross-linked biomaterial. Results revealed, the resultant biopolymer material exhibit high thermal stability with 5–6 fold increase in tensile strength compared to the plain AA and collagen materials. The degree of cross-linking was calculated as 75%. No cytotoxicity was observed for the cross-linked biopolymer material when tested with skin fibroblast cells and the material was biodegradable when treated with enzyme collagenase. With reference to bonding pattern analysis we found, AA cross-linked with type III collagen via (i) formation of covalent amide linkage between –COOH group of AA and ε-NH$_{2}$ group of type-III collagen as well as (ii) intermolecular multiple hydrogen bonding between alginic acid –OH group with various amino acid functional group of type-III collagen. Comparisons were made with other cross-linking agents also. For better understanding of bonding pattern, bioinformatics analysis was carried out and discussed in detail. The results of the study emphasize, AA acts as a suitable natural cross-linker for the preparation of wound dressing biopolymer material using collagen. The tensile strength and the thermal stability further added value to the resultant biopolymer.
Starting Page	1419
Ending Page	1429
Page Count	11
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	22
Issue Number	6
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2011-05-06
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Characterization and Evaluation of Materials Metallic Materials Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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