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| Content Provider | Springer Nature Link |
|---|---|
| Author | Saito, Hirofumi Murabayashi, Shun Mitamura, Yoshiri Taguchi, Tetsushi |
| Copyright Year | 2007 |
| Abstract | We have developed a naturally-derived crosslinker named malic acid derivative (MAD). In the present study, we prepared alkali-treated collagen (AlCol) gels with different crosslinkers including MAD and commercially available crosslinkers such as 1-ethyl-3-(3(′-dimethylaminopropyl) carbodiimide (EDC) and glutaraldehyde (GA). There are named as AlCol-MAD, AlCol-EDC, and AlCol-GA. We then compared their physicochemical properties. The residual amino groups in AlCol-MAD were not detected at MAD concentrations higher than 30 mM. On the other hand, the residual amino groups in AlCol-EDC and AlCol-GA were detected at crosslinker concentrations of 30 mM. The swelling ratios of AlCol-MAD, AlCol-EDC, and AlCol-GA decreased with increasing crosslinker concentration. Enzymatic degradation rate of AlCol-GA was slower than that of AlCol-MAD and AlCol-EDC. The cytotoxicity of MAD was clearly lower than that of EDC and GA. The number of adhered L929 on AlCol-MAD was higher than on AlCol-EDC and AlCol-GA after incubation for 1 day. After the culture for 3 and 7 days, excellent growth of L929 was observed on AlCol-MAD. These results suggested that MAD was excellent crosslinker for the reactivity with amino groups and cytocompatibility. Therefore, the resulting AlCol-MAD has potential for various biomedical applications like tissue engineering scaffolds and carrier for drug delivery systems. |
| Starting Page | 1297 |
| Ending Page | 1305 |
| Page Count | 9 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 19 |
| Issue Number | 3 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2007-09-13 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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