NDLI: Structural heterogeneity of pharmaceutical compacts probed by micro-indentation

Content Provider	Springer Nature Link
Author	Lee, Jonghwi
Copyright Year	2007
Abstract	Indentation has been used for several decades to conveniently assess the hardness and modulus of various compacts. However, this measurement is dependent on the size of the indentation area from a few nanometers to several millimeters, which is determined by the maximum indentation force (MIF). Micro-indentation often loses its ability to give an accurate representation of the hardness due to its relatively small micron-size indentation area compared with the dimensions of the structural inhomogeneity of compacts. This study used a different approach to micro-indentation by examining whether this method can probe the inhomogeneity of compacts with varying MIF. Two typical pharmaceutical excipients, one brittle and one ductile, were used as model compacts. The representative hardness and modulus values were available when the MIF was >1000 mN. Changes in the standard deviation of the indentation hardness reflected the structural inhomogeneity of the compacts, which was found to increase with decreasing MIF to below 800 mN in the case of the microcrystalline cellulose compacts. The information on the structural inhomogeneity obtained by micro-indentation appears to be consistent with the observations from microscopy investigations. Anisotropy and other related structural information could be readily obtained by probing the two different surfaces of compacts with changing MIF, one parallel and the other perpendicular to the compaction pressure direction.
Starting Page	1981
Ending Page	1990
Page Count	10
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	19
Issue Number	5
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2007-10-18
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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