NDLI: Inclusion complex formation of α- and β-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study

Content Provider	Springer Nature Link
Author	Terekhova, Irina V. Tikhova, Marina N. Volkova, Tatyana V. Kumeev, Roman S. Perlovich, German L.
Copyright Year	2010
Abstract	Possibility of encapsulation of riboflavin and alloxazine by α- and β-cyclodextrins in aqueous solution was studied by $^{1}$H NMR and solubility methods. Thermodynamic parameters of 1:1 inclusion complex formation (K, Δ$_{c}$G$^{0}$, Δ$_{c}$H$^{0}$ and Δ$_{c}$S$^{0}$) were obtained and analyzed in terms of influence of reagent’s structure on complexation process. It was shown that α-cyclodextrin displays low binding affinity to riboflavin and alloxazine. On the contrary, β-cyclodextrin forms with riboflavin and alloxazine more stable inclusion complexes. Binding is accompanied by the negative enthalpy and entropy changes that are determined by predominance of van der Waals interactions and possible H-bonding. The presence of ribityl substituent in riboflavin molecule prevents the deep penetration of this compound into macrocyclic cavity. Proposed on the basis of $^{1}$H NMR data the partial insertion of the hydrophobic part of riboflavin and alloxazine molecules into the β-cyclodextrin cavity causes the enhancement of aqueous solubility of the encapsulated substances. In comparison with α-cyclodextrin, the solubilizing effect of β-cyclodextrin is more pronounced due to its higher binding affinity to alloxazine and riboflavin.
Starting Page	167
Ending Page	172
Page Count	6
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	69
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-07-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inclusion complex formation Cyclodextrin Riboflavin Alloxazine Thermodynamics Crystallography Food Science Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Inclusion Complex Formation Between Modified Cyclodextrins and Riboflvin and Alloxazine in Aqueous Solution

Experimental Analysis of Complex Formation of Niflumic Acid with β-Cyclodextrins

A thermodynamic study of α-, β-, and γ-cyclodextrin-complexed m-methyl red in alkaline solutions

Inclusion complex formation of α- and β-cyclodextrins with aminobenzoic acids in aqueous solution studied by $^{1}$H NMR

Inclusion complex of α-lipoic acid and modified cyclodextrins

Thermodynamic study on inclusion complex formation of riboflavin with hydroxypropyl-β-cyclodextrin in water

Thermodynamic Data for the Complex Formation of Alkylamines and Their Hydrochlorides with α-Cyclodextrin in Aqueous Solution

Inclusion complex characterization between progesterone and hydroxypropyl-β-cyclodextrin in aqueous solution by NMR study

$^{1}$H NMR and calorimetric study on binding ability of cyclodextrins to isomeric pyridinecarboxylic acids in aqueous solution

Inclusion complex formation of α- and β-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study

Similar Documents

Inclusion Complex Formation Between Modified Cyclodextrins and Riboflvin and Alloxazine in Aqueous Solution

Experimental Analysis of Complex Formation of Niflumic Acid with β-Cyclodextrins

A thermodynamic study of α-, β-, and γ-cyclodextrin-complexed m-methyl red in alkaline solutions

Inclusion complex formation of α- and β-cyclodextrins with aminobenzoic acids in aqueous solution studied by $^{1}$H NMR

Inclusion complex of α-lipoic acid and modified cyclodextrins

Thermodynamic study on inclusion complex formation of riboflavin with hydroxypropyl-β-cyclodextrin in water

Thermodynamic Data for the Complex Formation of Alkylamines and Their Hydrochlorides with α-Cyclodextrin in Aqueous Solution

Inclusion complex characterization between progesterone and hydroxypropyl-β-cyclodextrin in aqueous solution by NMR study

$^{1}$H NMR and calorimetric study on binding ability of cyclodextrins to isomeric pyridinecarboxylic acids in aqueous solution

Inclusion complex formation of α- and β-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study