NDLI: Inclusion Complex Formation Between Modified Cyclodextrins and Riboflvin and Alloxazine in Aqueous Solution

Content Provider	Springer Nature Link
Author	Terekhova, Irina V. Koźbiał, Malgorzata Kumeev, Roman S. Alper, Gennady A.
Copyright Year	2011
Abstract	Inclusion complex formation of hydroxypropylated α-, β- and γ-cyclodextrins with riboflavin (vitamin B$_{2}$) and alloxazine was studied by spectroscopic and solubility methods. Alloxazine, which is a structural analog of riboflavin, was considered in order to evaluate the role of ribityl and methyl substituents in complexation. Thermodynamic parameters for 1:1 complex formation were obtained and analyzed in terms of influence of the reagent structure on the binding process. It was shown that the cavity of hydroxypropyl-β-cyclodextrin is more appropriate for formation of stable complexes. The complexes are enthalpy stabilized, due to prevalence of van der Waals interactions and possible hydrogen bonding. The partial insertion of riboflavin into the cyclodextrin cavity was revealed by $^{1}$H NMR and computer modeling. The ribityl side chain, which prevents deep inclusion, is located nearby the wider rim of the cyclodextrin molecule and can undergo destruction. Penetration of the alloxazine molecule into the macrocyclic cavity is deeper and accompanied by formation of more stable inclusion complexes. Hydroxypropyl-β-cyclodextrin was found to be the more efficient solubilizing agent for riboflavin and alloxazine, whereas a stabilization action of cyclodextrins towards riboflavin was not observed.
Starting Page	1435
Ending Page	1446
Page Count	12
File Format	PDF
ISSN	00959782
Journal	Journal of Solution Chemistry
Volume Number	40
Issue Number	8
e-ISSN	15728927
Language	English
Publisher	Springer US
Publisher Date	2011-07-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inclusion complex Modified cyclodextrins Riboflavin Alloxazine Thermodynamics Physical Chemistry Geochemistry Industrial Chemistry/Chemical Engineering Condensed Matter Physics Inorganic Chemistry Oceanography
Content Type	Text
Resource Type	Article
Subject	Biochemistry Molecular Biology Biophysics Physical and Theoretical Chemistry

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