NDLI: Freeze-Dried Complexes of Furosemide with β-Cyclodextrin Derivatives

Content Provider	Springer Nature Link
Author	Kreaz, R.M. Amin Abu Eida, E.Y. Erős, I. Kata, M.
Copyright Year	1999
Abstract	A freeze-drying method was used to prepare complexes of furosemide (guest) with three derivatives of β-cyclodextrin (hosts) in different molecular ratios in order to increase the aqueous solubility and rate of dissolution of the drug, and also to study the influence of this method on different parameters of the guest and the host, such as the diffusion rate constant and the partition coefficient, and additionally the surface tension activity of the host (if any). The hosts were found to have significant, increasing effects on the solubility and the rate of dissolution of furosemide. X-ray diffraction confirmed the host–guest interaction, in support of the earlier results. The freeze-drying method increased the diffusion rate of the drug in complex form, while the partition coefficient varied with the type of β-cyclodextrin in the product. It is well known that CD derivatives are highly surface active which gives rise to their hemolytic action. Our observations showed that their presence with furosemide in complex form might decrease (if not diminish) the hemolytic action.
Starting Page	39
Ending Page	48
Page Count	10
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	34
Issue Number	1
e-ISSN	15731111
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1999-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Food Science Organic Chemistry Crystallography
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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