NDLI: Studies on Inclusion Complexes of Felodipine with β-Cyclodextrin

Content Provider	Springer Nature Link
Author	Mielcarek, Jadwiga
Copyright Year	1998
Abstract	The inclusion behaviour of β-cyclodextrin(β-CD) with felodipine (FL) as a guest moleculewas studied. Inclusion complexes were obtained by thekneading method in a binary or ternary system with anaddition of polyethylene glycol 6000. Formation ofinclusion complexes was studied by IR spectroscopy,differential scanning calorimetry (DSC), and$^{13}$C-NMR. It has been shown that an aromaticphenyl ring was involved in the process ofcomplexation, and that in the solid clathrates thesolubility of FL increased two fold when compared tothe physical mixture, while it increased 10 fold inliquid three-component complexes. Moreover, thephotochemical stability of felodipine was studied inits crystalline form and in the inclusion complexeswith β-CD. Quantitative assessment of thefelodipine photochemical decomposition was made on thebasis of the rate constants of decomposition (k) inthe first order kinetic reaction, half life time(t$_{0.5}$) and the time of decomposition of 10% of thecompound (t$_{0.1}$). It was shown that complexationof FL with β-CD causes a two fold increase ofthe rate of the photodegradation process.
Starting Page	243
Ending Page	252
Page Count	10
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	30
Issue Number	3
e-ISSN	15731111
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Food Science Organic Chemistry Crystallography
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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