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| Content Provider | Springer Nature Link |
|---|---|
| Author | Shah, Manali Pore, Yogesh Dhawale, Shashikant Burade, Kishorkumar Kuchekar, Bhanudas |
| Copyright Year | 2012 |
| Abstract | The physicochemical properties of spray dried micro-complexes of cefuroxime axetil (CFA) with hydroxypropyl-β-cyclodextrin (HPβCD) in presence and/or absence of ternary components polyvinylpyrrolidone K30 (PVP K30), hydroxypropylmethylcellulose (HPMC), poloxamer 188 and/or polyethylene glycol 4000 (PEG 4000) along with Aerosil$^{®}$200 as an adsorbent were investigated. The phase solubility studies revealed A$_{L}$ type of solubility curve in binary as well as ternary systems. The stability constant 382.70 ± 2.4 M$^{−1}$ of binary system i.e. CFA with HPβCD was significantly improved to 427.84 ± 3.8, 447.09 ± 4.3, 488.28 ± 4.6 and 502.21 ± 5.1 M$^{−1}$ in presence of PVP K30, HPMC, poloxamer 188 and PEG 4000 respectively indicating positive effect of their addition. The micro-complexes of CFA were characterized by Fourier transformation infrared spectroscopy, X-ray powder diffractometry, differential scanning calorimetry, scanning electron microscopy, particle size analysis, and dissolution. In all characterization studies, ternary systems performed better in comparison to binary systems as a result of synergistic effect of ternary complexation as well as particle size reduction achieved by a spray drying technology. |
| Starting Page | 391 |
| Ending Page | 401 |
| Page Count | 11 |
| File Format | |
| ISSN | 13883127 |
| Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
| Volume Number | 76 |
| Issue Number | 3-4 |
| e-ISSN | 15731111 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-08-03 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cefuroxime axetil Hydroxypropyl-β-cyclodextrin Spray dried Ternary Micro-complexes Organic Chemistry Food Science Crystallography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Food Science |
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