NDLI: Morphological and functional features of the blood in humans during a nine-day stay in an oxyargon environment with various oxygen contents

Content Provider	Springer Nature Link
Author	Ivava, S. M. Morukov, B. V. Maksimov, G. V. Churin, A. A. Yarlykova, Yu. V. Labetskaya, O. I.
Copyright Year	2012
Abstract	Biochemical parameters of the red blood and oxygen transportation of hemoglobin by erythrocytes were studied in subjects who volunteered for chamber experiments (0.15 MPa) with normal and hypoxic oxygen-nitrogen-argon (O2-N2-Ar) gas environments. Erythrocyte metabolism, lipid and phospholipid spectra, and the efficiency of oxygen releasing and retention by hemoglobin were studied in the period of collecting baseline data, on the sixth day of stay in a hyperbaric normoxic O2-N2-Ar gas environment (13.7% O2), on the third day of stay in a hyperbaric hypoxic O2-N2-Ar environment (9.9% O2), and on the first and the tenth days of a postexperimental rehabilitation period. The high pressure, hypoxia, and the subsequent decompression resulted in a decrease in the ATP levels, which is probably due to the changes within the membrane and increased G6PD activity associated with cell repair. Changes in the lipid and phospholipid compositions of the membrane indicate an altered phase state of the plasma membrane, i.e., an increased viscosity, which may be related to possible changes in the membrane’s permeability. As a rule, hyperbaric conditions lead to a decrease in oxygen transportation in the blood of the subjects. Hypoxia against the background of hyperbaria had different effects on the subjects, namely, the absence of changes, a decrease, or an increase in the efficiency of oxygen transportation, which can be explained by the selectivity and individual sensitivity of the subjects to the experimental factors. A decrease in the efficiency of oxygen transportation by hemoglobin is most likely to be related to an increase in the viscosity of the plasma membrane, which may affect the conformation of hemoporphyrin of the membrane-bound hemoglobin and obstruct oxygen transportation through the membrane.
Starting Page	786
Ending Page	787
Page Count	2
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	38
Issue Number	7
e-ISSN	16083164
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-12-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Life Sciences Human Physiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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