NDLI: Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Please wait, while we are loading the content...

A cost-effectiveness analysis of prophylactic surgery versus gynecologic surveillance for women from hereditary non-polyposis colorectal cancer (HNPCC) Families

Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer

Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch Syndrome

Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Tunisian family with FAP

The sex ratio and age of onset features of gastric cancer patients in hereditary diffuse gastric cancer families

Factors associated with an individuals’ decision to withdraw from genetic counseling for BRCA1 and BRCA2 genes mutations: are personality traits involved?

Malignant fibrous histiocytoma is a rare Lynch syndrome-associated tumor in two German families

Cancer worry among Norwegian male BRCA1/2 mutation carriers

Familial colorectal cancer: eleven years of data from a registry program in Switzerland

Low penetrance hereditary retinoblastoma in a family: what should we consider in the genetic counselling process and follow up?

Familial Cancer : Volume 10, Issue 2, June 2011

Familial Cancer : Volume 10, Issue 3, Supplement,May 2011

Familial Cancer : Volume 10, Issue 2, Supplement,April 2011

Familial Cancer : Volume 10, Issue 1, Supplement,March 2011

Familial Cancer : Volume 10, Issue 1, March 2011

Familial Cancer : Volume 9

Familial Cancer : Volume 8

Familial Cancer : Volume 7

Familial Cancer : Volume 6

Familial Cancer : Volume 5

Familial Cancer : Volume 4

Familial Cancer : Volume 3

Familial Cancer : Volume 2

Familial Cancer : Volume 1

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Content Provider	Springer Nature Link
Author	Kiely, B. E. Friedlander, M. L. Milne, R. L. Stanhope, L. Russell, P. Jenkins, M. A. Weideman, P. McLachlan, S. A. Grant, P. Hopper, J. L. Phillips, K. A.
Copyright Year	2011
Abstract	The aim of this study was to describe the type of risk-reducing gynaecologic surgery (RRGS) and the extent of pathological evaluation being undertaken for Australasian women at high familial risk of pelvic serous cancer. Surgical and pathology reports were reviewed for women with BRCA1/BRCA2 mutations, or a family history of breast and ovarian cancer, who underwent RRGS between 1998 and 2008. “Adequate” surgery was defined as complete removal of all ovarian and extra-uterine fallopian tube tissue. “Adequate” pathology was defined as paraffin embedding of all removed ovarian and tubal tissue. Predictors of adequacy were assessed using logistic regression. There were 201 women, including 173 mutation carriers, who underwent RRGS. Of these, 91% had adequate surgery and 23% had adequate pathology. Independent predictors of adequate surgery were surgeon type (OR = 20; 95% CI 2–167; P = 0.005 for gynaecologic oncologists versus general gynaecologists), more recent surgery (OR = 1.33/year; 95% CI 1.07–1.67; P = 0.012) and younger patient age (OR = 0.93/year of age; 95% CI 0.87–0.99; P = 0.028). Independent predictors of adequate pathology were more recent surgery (OR = 1.26/year; 95% CI 1.06–1.49; P = 0.008) and surgeon type (OR = 3.1; 95% CI 1.4–6.7; P = 0.004 for gynaecologic oncologists versus general gynaecologists). Four serous ovarian cancers and one endometrioid endometrial cancer were detected during surgery or pathological examination. In conclusion Australasian women attending a specialist gynaecologic oncologist for RRGS are most likely to have adequate surgery and pathological examination. Additional education of clinicians and consumers is needed to ensure optimal surgery and pathology in these women.
Starting Page	505
Ending Page	514
Page Count	10
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	10
Issue Number	3
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-03-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	BRCA1/BRCA2 mutations Cancer prevention Ovarian cancer Prophylactic salpingo-oophorectomy Risk-reducing surgery Epidemiology Biomedicine general Cancer Research Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Improved quality of risk-reducing salpingo-oophorectomy in Australasian women at high risk of pelvic serous cancer

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Baseline and post prophylactic tubal–ovarian surgery CA125 levels in BRCA1 and BRCA2 mutation carriers

Adequacy of risk-reducing gynaecologic surgery in brca1 or brca2 (2011).

Psychosocial factors and uptake of risk-reducing salpingo-oophorectomy in women at high risk for ovarian cancer

Oophorectomy in brca1 or brca2 mutation carriers.

The effect of personal medical history and family history of cancer on the uptake of risk-reducing salpingo-oophorectomy

Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Similar Documents

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Improved quality of risk-reducing salpingo-oophorectomy in Australasian women at high risk of pelvic serous cancer

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer

Baseline and post prophylactic tubal–ovarian surgery CA125 levels in BRCA1 and BRCA2 mutation carriers

Adequacy of risk-reducing gynaecologic surgery in brca1 or brca2 (2011).

Psychosocial factors and uptake of risk-reducing salpingo-oophorectomy in women at high risk for ovarian cancer

Oophorectomy in brca1 or brca2 mutation carriers.

The effect of personal medical history and family history of cancer on the uptake of risk-reducing salpingo-oophorectomy

Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations

Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer