NDLI: Release of beryllium from mineral ores in artificial lung and skin surface fluids

Content Provider	Springer Nature Link
Author	Duling, Matthew G. Stefaniak, Aleksandr B. Lawrence, Robert B. Chipera, Steve J. Abbas Virji, M.
Copyright Year	2011
Abstract	Exposure to some manufactured beryllium compounds via skin contact or inhalation can cause sensitization. A portion of sensitized persons who inhale beryllium may develop chronic beryllium disease (CBD). Little is understood about exposures to naturally occurring beryllium minerals. The purpose of this study was to assess the bioaccessibility of beryllium from bertrandite ore. Dissolution of bertrandite from two mine pits (Monitor and Blue Chalk) was evaluated for both the dermal and inhalation exposure pathways by determining bioaccessibility in artificial sweat (pH 5.3 and pH 6.5), airway lining fluid (SUF, pH 7.3), and alveolar macrophage phagolysosomal fluid (PSF, pH 4.5). Significantly more beryllium was released from Monitor pit ore than Blue Chalk pit ore in artificial sweat buffered to pH 5.3 (0.88 ± 0.01% vs. 0.36 ± 0.00%) and pH 6.5 (0.09 ± 0.00% vs. 0.03 ± 0.01%). Rates of beryllium released from the ores in artificial sweat were faster than previously measured for manufactured forms of beryllium (e.g., beryllium oxide), known to induce sensitization in mice. In SUF, levels of beryllium were below the analytical limit of detection. In PSF, beryllium dissolution was biphasic (initial rapid diffusion followed by latter slower surface reactions). During the latter phase, dissolution half-times were 1,400 to 2,000 days, and rate constants were ~7 × 10−10 g/(cm2·day), indicating that bertrandite is persistent in the lung. These data indicate that it is prudent to control skin and inhalation exposures to bertrandite dusts.
Starting Page	313
Ending Page	322
Page Count	10
File Format	PDF
ISSN	02694042
Journal	Environmental Geochemistry and Health
Volume Number	34
Issue Number	3
e-ISSN	15732983
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-08-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Beryllium Bioaccessibility Minerals Sensitization Chronic beryllium disease Exposure Soil Science & Conservation Geochemistry Terrestrial Pollution Environmental Health Environmental Chemistry Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Geochemistry and Petrology Environmental Engineering Water Science and Technology

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