NDLI: Oral bioaccessibility of trace metals in household dust: a review

Content Provider	Springer Nature Link
Author	Turner, Andrew
Copyright Year	2011
Abstract	Because household dust is a heterogeneous assortment of particles derived from a multitude of diverse sources, concentrations of toxicants, like trace metals, vary widely among sample populations. For risk assessment purposes, the bioaccessibility of a trace metal, or its degree of solubilization in the human lung or digestive environment, provides a better metric of its potential health impact than its total concentration. In this paper, the relatively little direct information that exists on the in vitro oral bioaccessibilities of metals in household dust is reviewed. Data and mechanisms from studies involving better characterized geosolids, like soil and street dust, or metal-rich components thereof, such as paints, are also extrapolated to the household setting, although use of these solids as surrogates of household dust is not recommended. The bioaccessibility of a given metal is highly variable in the household setting; for instance, reported accessibilities of Pb in fluids that mimic the human stomach range from 25 to 80%, and accessibility is usually, but not always, reduced when conditions are altered to mimic the intestine. While part of this variation reflects the inherent heterogeneity of samples arising from local to regional differences in geology, industrial emissions, and domestic (and cultural) practices, considerable variation results from the precise means by which bioaccessibility is determined in vitro. It is recommended, therefore, that the effects of physicochemical variables, and in particular, the solid to fluid ratio and the pH of the stomach phase, are studied systematically such that appropriate algorithms or corrections may be factored into measures of bioaccessibility obtained under operationally defined default conditions.
Starting Page	331
Ending Page	341
Page Count	11
File Format	PDF
ISSN	02694042
Journal	Environmental Geochemistry and Health
Volume Number	33
Issue Number	4
e-ISSN	15732983
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-03-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Household dust Trace metals Bioaccessibility PBET Stomach Intestine Geochemistry Environmental Health Public Health/Gesundheitswesen Environmental Chemistry Terrestrial Pollution Soil Science & Conservation
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Geochemistry and Petrology Environmental Engineering Water Science and Technology

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