NDLI: MHC class I genes of birds of prey: isolation, polymorphism and diversifying selection

Content Provider	Springer Nature Link
Author	Alcaide, Miguel Edwards, Scott V. Cadahía, Luis Negro, Juan J.
Copyright Year	2008
Abstract	The threat of emerging infectious diseases encourages the investigation of functional loci related to host resilience, such as those belonging to the major histocompatibility complex (MHC). Through careful primer design targeting to conserved regions of MHC class I sequences in birds, we successfully amplified a genomic fragment spanning exons 2–4 in three birds of prey. The identification of a highly conserved region within intron 2 allowed cross-amplifying complete exon 3 sequences in diurnal raptors, owls and New World vultures. We found evidence through PCR and cloning for 1–2 polymorphic class I loci, although this is almost certainly an underestimate. Inferences of diversifying selection in the kestrel MHC revealed that the two major regions of exon 3 exhibiting positive selection mostly agree with those described for the human HLA-A2 molecule. In contrast to passerines, where a high incidence of gene duplications and pseudogenes has been commonly documented, birds of prey emerge as nice model species for the investigation of the evolutionary significance and conservation implications of MHC diversity in vertebrates.
Starting Page	1349
Ending Page	1355
Page Count	7
File Format	PDF
ISSN	15660621
Journal	Conservation Genetics
Volume Number	10
Issue Number	5
e-ISSN	15729737
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-08-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adaptive variation Conservation genetics Immunogenetics Genetic diversity Raptors Infectious diseases Plant Sciences Evolutionary Biology Conservation Biology/Ecology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics

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Erratum to: MHC class I genes of birds of prey: isolation, polymorphism and diversifying selection

Erratum to: MHC class I genes of birds of prey: isolation, polymorphism and diversifying selection

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MHC class I genes of birds of prey: isolation, polymorphism and diversifying selection