NDLI: Pericentric and centromeric transcription: a perfect balance required

Content Provider	Springer Nature Link
Author	Hall, Laura E. Mitchell, Sarah E. O’Neill, Rachel J.
Copyright Year	2012
Abstract	The pericentromere and centromere regions of the genome have previously been considered tightly compacted and transcriptionally inert. However, there is mounting evidence that these regions not only actively produce transcripts but that these pericentric and centromeric transcripts are also vital to maintaining genome stability and proper cell division. In this review, we define the pericentromere and centromere of eukaryotic chromosomes in terms of their histone modifications and their nascent transcripts. In addition, we present the currently known roles these transcripts play in heterochromatin formation, development, and differentiation, as well as their interaction with centromeric proteins, and ultimately centromere function. Recent work has added considerable complexity to the theoretical framework defining the innate requirement for pericentric and centromeric transcription. It is clear that maintaining a fine balance of transcriptional output is critical, as deviations from this balance result in centromere disfunction and genomic instability.
Starting Page	535
Ending Page	546
Page Count	12
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	20
Issue Number	5
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-07-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Centromere transcripts Pericentromere transcripts CENP-A Genome instability Animal Genetics and Genomics Cell Biology Plant Genetics & Genomics Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics

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