NDLI: Mammographic density and breast cancer risk by family history in women of white and Asian ancestry

Content Provider	Springer Nature Link
Author	Maskarinec, Gertraud Nakamura, Kaylae L. Woolcott, Christy G. Conroy, Shann M. Byrne, Celia Nagata, Chisato Ursin, Giske Vachon, Celine M.
Copyright Year	2015
Abstract	Mammographic density, i.e., the radiographic appearance of the breast, is a strong predictor of breast cancer risk. To determine whether the association of breast density with breast cancer is modified by a first-degree family history of breast cancer (FHBC) in women of white and Asian ancestry, we analyzed data from four case–control studies conducted in the USA and Japan.The study population included 1,699 breast cancer cases and 2,422 controls, of whom 45 % reported white (N = 1,849) and 40 % Asian (N = 1,633) ancestry. To standardize mammographic density assessment, a single observer re-read all mammograms using one type of interactive thresholding software. Logistic regression was applied to estimate odds ratios (OR) while adjusting for confounders.Overall, 496 (12 %) of participants reported a FHBC, which was significantly associated with breast cancer risk in the adjusted model (OR 1.51; 95 % CI 1.23–1.84). There was a statistically significant interaction on a multiplicative scale between FHBC and continuous percent density (per 10 % density: p = 0.03). The OR per 10 % increase in percent density was higher among women with a FHBC (OR 1.30; 95 % CI 1.13–1.49) than among those without a FHBC (OR 1.14; 1.09–1.20). This pattern was apparent in whites and Asians. The respective ORs were 1.45 (95 % CI 1.17–1.80) versus 1.22 (95 % CI 1.14–1.32) in whites, whereas the values in Asians were only 1.24 (95 % CI 0.97–1.58) versus 1.09 (95 % CI 1.00–1.19).These findings support the hypothesis that women with a FHBC appear to have a higher risk of breast cancer associated with percent mammographic density than women without a FHBC.
Starting Page	621
Ending Page	626
Page Count	6
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	4
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-03-12
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast neoplasms Mammographic density Family history Epidemiology Risk factor Effect modification Cancer Research Biomedicine general Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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