NDLI: Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer

Content Provider	Springer Nature Link
Author	Murtaugh, Maureen A. Curtin, Karen Sweeney, Carol Wolff, Roger K. Holubkov, Richard Caan, Bette J. Slattery, Martha L.
Copyright Year	2007
Abstract	Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone. Data were from participants in a case–control study conducted in Northern California and Utah (751 cases and 979 controls). We examined independent associations and interactions of folate, B vitamins, methionine, alcohol, and MTHFR polymorphisms (MTHFR C677T and A1298C) with rectal cancer. Dietary folate intake was associated with a reduction in rectal cancer OR 0.66, 95% CI 0.48–0.92 (>475 mcg day compared to < = 322 mcg) as was a combination of nutrient intakes contributing to higher methyl donor status (OR 0.79, 95% CI 0.66–0.95). Risk was reduced among women with the 677 TT genotype (OR 0.54, 95% CI 0.30–0.9), but not men (OR 1.11, 95% CI 0.70–1.76) and with the 1298 CC genotype in combined gender analysis (OR 0.67, 95% CI 0.46–0.98). These data are consistent with a protective effect of increasing dietary folate against rectal cancer and suggest a protective role of the MTHFR 677 TT genotype in women and 1298 CC in men and women. Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer.
Starting Page	153
Ending Page	163
Page Count	11
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	18
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2007-01-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Diet Pteroylpolyglutamic Acids Rectal Neoplasms Polymorphism Genetic Cancer Research Public Health/Gesundheitswesen Hematology Oncology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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