NDLI: Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom)

Content Provider	Springer Nature Link
Author	Dorak, M. Tevfik Pearce, Mark S. Hammal, Donna M. McNally, Richard J. Q. Parker, Louise
Copyright Year	2007
Abstract	Higher birth weight and maternal history of miscarriage has been associated with an increased risk of childhood leukemia. The possibility that this association may be sex-specific has not been explored in detail in previous studies.In a retrospective case-control study, 732 childhood (≤14 years) cancer cases from a population-based Registry in Northern England whose hospital birth records could be accessed and 3,723 controls matched for date and hospital of birth to the cases were compared. We examined birth weight for sex-specific associations with childhood cancer. Conditional logistic regression analysis was used for statistical evaluation of associations.In acute lymphoblastic leukemia (ALL) (225 cases and 1,163 matched controls), birth weight and sex showed a strong interaction (P = 0.003). In boys with ALL, but not in girls, there was a nonlinear association with birth weight (P for trend = 0.008; OR = 3.05 for the highest quintile compared to the second lowest quintile, 95% CI = 1.40–6.64; P = 0.005). When birth weights were adjusted using UK standards for gestational age and sex, the risk associations were similar in statistical significance and magnitude. Maternal history of miscarriage showed an association with all cancers and individually with ALL. The miscarriage association with ALL was statistically significant in boys only (OR = 1.91, 95% CI = 1.07–3.42; P = 0.03). A multivariable model for ALL containing other examined maternal and reproductive variables confirmed the independence of the birth weight and miscarriage associations. There was no birth weight or miscarriage associations in other cancers.This study confirmed the risk associations with birth weight and miscarriages in childhood ALL. Statistically significant association of size at birth suggested marked differences in etiology between girls and boys.
Starting Page	219
Ending Page	228
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	18
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2007-01-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Birth weight Miscarriage Case–control studies Sex factors Epidemiology Childhood leukemia Cancer Research Public Health/Gesundheitswesen Hematology Oncology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)

Childhood Cancer and Social Contact: the Role of Paternal Occupation (United Kingdom)*

Sun exposure, birth weight, and childhood lymphomas: a case control study in Greece

Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)

Associations of birth weight and physical activity with sex steroids in preschool Japanese children

Malignant neoplasms of the brain during childhood: the role of prenatal and neonatal factors (United Kingdom)

Life course breast cancer risk factors and adult breast density (United Kingdom)

Obesity and the risk of Hodgkin lymphoma (United Kingdom)

Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom)

Similar Documents

Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)

Childhood Cancer and Social Contact: the Role of Paternal Occupation (United Kingdom)*

Sun exposure, birth weight, and childhood lymphomas: a case control study in Greece

Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)

Associations of birth weight and physical activity with sex steroids in preschool Japanese children

Malignant neoplasms of the brain during childhood: the role of prenatal and neonatal factors (United Kingdom)

Life course breast cancer risk factors and adult breast density (United Kingdom)

Obesity and the risk of Hodgkin lymphoma (United Kingdom)

Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom)