NDLI: Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case

Content Provider	Springer Nature Link
Author	Lee, Jung Eun Wei, Esther K. Fuchs, Charles S. Hunter, David J. Lee, I Min Selhub, Jacob Stampfer, Meir J. Willett, Walter C. Ma, Jing Giovannucci, Edward
Copyright Year	2012
Abstract	Few prospective studies have examined the associations between blood levels of folate, in conjunction with methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and colorectal cancer. We evaluated the associations between plasma folate, MTHFR C677T, and A1298C, and colorectal cancer in three large prospective studies: the Nurses’ Health Study, the Health Professionals Follow-up Study, and the Physicians’ Health Study. A total of 602 incident cases were identified and individually matched to controls who provided blood specimens. We used conditional logistic regression to calculate the relative risk (RR) and 95% confidence interval (95% CI) and then pooled the estimates using a random effects model. We found a lower risk of colorectal cancer among participants with low plasma folate levels: compared with the lowest quartile, RRs (95% CIs) for each successively higher quartile of plasma folate levels were 1.55 (1.14–2.11), 1.37 (1.00–1.88), and 1.47 (1.07–2.01; P for trend = 0.10). For the MTHFR polymorphisms, RRs (95% CIs) were 0.62 (0.44–0.90) for 677TT versus CC/CT and 0.68 (0.31–1.51) for 1298CC versus AC/AA, and these lower-risk genotypes were associated with lower circulating plasma folate levels. When we partitioned the variation in plasma folate levels, variation due to folate intake was not positively associated with colorectal cancer risk. We found that low plasma folate levels were associated with lower risk of colorectal cancer. The reasons underlying a lower risk of colorectal cancer with low plasma folate levels require elucidation because plasma folate levels can reflect dietary intake, genetic influences, and other factors.
Starting Page	537
Ending Page	545
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	23
Issue Number	4
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-02-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Folate Methylenetetrahydrofolate reductase (MTHFR) Colorectal cancer Cancer Research Hematology Oncology Biomedicine general Public Health/Gesundheitswesen Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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