NDLI: Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

Content Provider	Springer Nature Link
Author	Kelly, Rachel S. Roulland, Sandrine Morgado, Ester Sungalee, Stéphanie Jouve, Nathalie Tumi, Rosario Krogh, Vittorio Panico, Salvatore Polidoro, Silvia Masala, Giovanna Sánchez, María José Chirlaque, Maria Dolores Sala, Núria Gurrea, Aurelio Barricarte Dorronsoro, Miren Travis, Ruth C. Riboli, Elio Gunter, Marc Murphy, Neil Vermeulen, Roel Bue de Mesquita, H. B. Peeters, Petra H. Trichopoulou, Antonia Trichopoulos, Dimitrios Lagiou, Pagona Nieters, Alexandra Canzian, Federico Kaaks, Rudolf Boeing, Heiner Weiderpass, Elisabete Stocks, Tanja Melin, Beatrice Overvad, Kim Tjønneland, Anne Olsen, Anja Brennan, Paul Johansson, Mattias Nadel, Bertrand Vineis, Paolo
Copyright Year	2015
Abstract	The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case–control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)+ as compared to t(14;18)− cases.Among incident FL cases, educational level (χ 2 p = 0.021) and height (χ 2 p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)HF] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)+ FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)− cases.These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.
Starting Page	1845
Ending Page	1855
Page Count	11
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-09-30
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Follicular lymphoma Translocation t(14;18) Height Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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