NDLI: Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

Content Provider	Springer Nature Link
Author	Sakoda, Lori C. Loomis, Melissa M. Doherty, Jennifer A. Neuhouser, Marian L. Barnett, Matt J. Thornquist, Mark D. Weiss, el S. Goodman, Gary E. Chen, Chu
Copyright Year	2011
Abstract	Studying gene–environment interactions may provide insight about mechanisms underpinning the reported association between chromosome 15q24-25.1 variation and lung cancer susceptibility.In a nested case–control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics. Intake of fruits and vegetables, their botanical groups, and specific nutrients were ascertained generally at baseline by food-frequency questionnaire.Several sets of SNPs in high linkage disequilibrium were found: one set associated with a 27–34% increase and two sets associated with a 13–19% decrease in risk per minor allele. Associations were most prominent for the set including the non-synonymous SNP rs16969968. The rs16969968-lung cancer association did not differ by intake level of most dietary factors examined, but was stronger for individuals diagnosed at <70 years of age or having a baseline smoking history of <40 cigarette pack-years.Our data suggests that diet has little influence on the relation between chromosome 15q24-25.1 variation and lung cancer risk.
Starting Page	449
Ending Page	461
Page Count	13
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	3
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-01-13
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lung cancer Genetic polymorphism Nicotinic acetylcholine receptors Diet Public Health/Gesundheitswesen Cancer Research Hematology Epidemiology Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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