NDLI: Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study

Content Provider	Springer Nature Link
Author	Johnson, Shane Koh, Woon Puay Wang, Renwei Govindarajan, Sugantha Yu, Mimi C. Yuan, Jian Min
Copyright Year	2011
Abstract	Coffee consumption has been associated with reduced markers of hepatic cell damage, reduced risk of chronic liver disease, and cirrhosis across a variety of populations. Data on the association between coffee consumption and risk of hepatocellular carcinoma (HCC), especially in high-risk populations, are sparse.This study examines the relationship between coffee and caffeine consumption, and the risk of developing HCC within the Singapore Chinese Health Study, a prospective cohort of 63,257 middle-aged and older Chinese men and women, a relatively high-risk population for HCC. Baseline data on coffee consumption and other dietary and lifestyle factors were collected through in-person interviews at enrollment between 1993 and 1998.As of 31 December 2006, 362 cohort participants had developed HCC. High levels of coffee or caffeine consumption were associated with reduced risk of HCC (p for trend < 0.05). Compared with non-drinkers of coffee, individuals who consumed three or more cups of coffee per day experienced a statistically significant 44% reduction in risk of HCC (hazard ratio 0.56, 95% confidence interval, 0.31–1.00, p = .049) after adjustment for potential confounders and tea consumption.These data suggest that coffee consumption may reduce the risk of developing HCC in Chinese in Singapore.
Starting Page	503
Ending Page	510
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	3
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-01-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Coffee Caffeine HCC Hepatocellular Liver cancer GGT Public Health/Gesundheitswesen Cancer Research Hematology Epidemiology Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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