NDLI: Dietary lignan intake and androgen receptor expression in breast tumors

Content Provider	Springer Nature Link
Author	Williams, AnnaLynn M. Bonner, Matthew Ochs Balcom, Heather M. Hwang, Helena Morrison, Carl McCann, Susan E.
Copyright Year	2014
Abstract	Lignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors.Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR.We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R 2 = 0.35).Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.
Starting Page	311
Ending Page	317
Page Count	7
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-12-04
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dietary lignans Androgen receptor Breast cancer Tissue microarray Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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