NDLI: Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk

Content Provider	Springer Nature Link
Author	Lowcock, Elizabeth C. Cotterchio, Michelle Boucher, Beatrice A.
Copyright Year	2013
Abstract	To investigate the association between intake of flaxseed—the richest source of dietary lignans (a class of phytoestrogens)—and breast cancer risk.A food frequency questionnaire was used to measure the consumption of flaxseed and flax bread by 2,999 women with breast cancer and 3,370 healthy control women who participated in the Ontario Women’s Diet and Health Study (2002–2003). Logistic regression was used to investigate associations between consumption of flaxseed and flax bread and breast cancer risk. Confounding by established and suspected breast cancer risk factors, as well as dietary factors, was assessed.Flaxseed or flax bread was consumed at least weekly by 21 % of control women. None of the 19 variables assessed were identified as confounders of the associations between flaxseed or flax bread and breast cancer risk. Consumption of flaxseed was associated with a significant reduction in breast cancer risk (odds ratio (OR) = 0.82, 95 % confidence interval (CI) 0.69–0.97), as was consumption of flax bread (OR = 0.77, 95 % CI 0.67–0.89).This Canadian study is, to our knowledge, the first to report on the association between flaxseed alone and breast cancer risk and has found that flaxseed intake is associated with a reduction in breast cancer risk. As dietary intake of flaxseed is modifiable, this finding may be of public health importance with respect to breast cancer prevention.
Starting Page	813
Ending Page	816
Page Count	4
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	24
Issue Number	4
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-01-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast neoplasms Flax Lignans Phytoestrogens Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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