NDLI: Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study

Content Provider	Springer Nature Link
Author	Jayasekara, Harindra MacInnis, Robert J. Hodge, Allison M. Hopper, John L. Giles, Graham G. Room, Robin English, Dallas R.
Copyright Year	2014
Abstract	Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime alcohol intake. We examined the associations between incident squamous cell carcinoma of the UADT (oral cavity, pharynx, larynx, and esophagus) and alcohol intake for different periods in life using data from the Melbourne Collaborative Cohort Study.Usual alcohol intake for 10-year periods from age 20 was calculated using recalled frequency and quantity of beverage-specific consumption. Cox regression with age as the time axis was performed to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for the associations of UADT cancer with alcohol intake for different periods in life compared with abstention.During a mean follow-up of 16.2 person-years, 98 incident cases of UADT cancer were identified. We observed a dose-dependent association between lifetime alcohol intake and the risk of UADT cancer (multivariable-adjusted HR 2.67, 95 % CI 1.27–5.60 for an intake of ≥40 g/day and multivariable-adjusted HR 1.16, 95 % CI 1.06–1.28 for a 10 g/day increment in intake). A positive association with baseline alcohol intake (multivariable-adjusted HR 1.12, 95 % CI 1.02–1.24 for a 10 g/day increment in intake) was found to be a slightly weaker predictor of risk than lifetime intake.Limiting alcohol intake from early adulthood may reduce UADT cancer risk.
Starting Page	297
Ending Page	301
Page Count	5
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-11-18
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alcohol Cancer Cohort Lifetime consumption Upper aero-digestive tract Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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