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| Content Provider | Springer Nature Link |
|---|---|
| Author | Takata, Yumie Cai, Qiuyin Beeghly Fadiel, Alicia Li, Honglan Shrubsole, Martha J. Ji, Bu Tian Yang, Gong Chow, Wong Ho Gao, Yu Tang Zheng, Wei Shu, Xiao Ou |
| Copyright Year | 2012 |
| Abstract | B vitamins and methionine have been postulated to have potential effects on carcinogenesis; however, findings from previous epidemiologic studies on B vitamins, methionine, and lung cancer risk are inconsistent. We investigated associations of dietary intakes of B vitamins (i.e., riboflavin, niacin, vitamin B6, folate, and vitamin B12) and methionine with lung cancer risk among female never smokers.The Shanghai Women’s Health Study, a population-based, prospective cohort study, included 74,941 women. During a median follow-up of 11.2 years, 428 incident lung cancer cases accrued among 71,267 women with no history of smoking or cancer at baseline. Baseline dietary intakes were derived from a validated, interviewer-administered food frequency questionnaire. Cancer incidence and vital status were ascertained through annual linkage to the Shanghai Cancer Registry and Shanghai Vital Statistics Registry databases and through biennial in-person follow-ups with participants. Adjusted hazard ratios (HR) and 95 % confidence intervals (CI) were calculated using Cox regression.Dietary riboflavin intake was inversely associated with lung cancer risk (HR = 0.62; 95 % CI = 0.43–0.89; p trend = 0.03 for the highest quartile compared with the lowest). A higher than median intake of methionine was associated with lower risk of lung cancer (HR = 0.78; 95 % CI = 0.60–0.99); however, there was no dose–response relation. Intakes of other B vitamins were not associated with lung cancer risk.Our study suggests that dietary riboflavin intake may be inversely associated with lung cancer risk among female never smokers, which warrants further investigation. |
| Starting Page | 1965 |
| Ending Page | 1975 |
| Page Count | 11 |
| File Format | |
| ISSN | 09575243 |
| Journal | Cancer Causes & Control |
| Volume Number | 23 |
| Issue Number | 12 |
| e-ISSN | 15737225 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-10-12 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | B vitamins Methionine Lung cancer Never smokers Women Biomedicine general Epidemiology Cancer Research Oncology Public Health Hematology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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