NDLI: Hemodynamic Response Function (HRF) in Epilepsy Patients with Hippocampal Sclerosis and Focal Cortical Dysplasia

Content Provider	Springer Nature Link
Author	Watanabe, Satsuki An, Dongmei Safi Harb, Mona Dubeau, François Gotman, Jean
Copyright Year	2014
Abstract	Simultaneous recording of electroencephalography and functional magnetic resonance imaging (EEG–fMRI) has recently been applied for mapping the hemodynamic changes related to epileptic activity. The aim of this study is to compare the hemodynamic response function (HRF) to epileptic spikes in patients with focal cortical dysplasia (FCD) and those with hippocampal sclerosis (HS). In EEG–fMRI studies, the HRF represents the temporal evolution of blood oxygenation level-dependent signal changes. Several studies demonstrated that amplitude and latency of the HRF are variable in patients with epilepsy. However, the consistency of HRF parameters with underlying brain pathology is unknown. In this study, we examined 14 patients with FCD and 12 with unilateral HS selected from our EEG–fMRI database and compared the amplitude and latency of the HRF peak. We analyzed (1) HRFs in peak activation clusters, (2) HRFs in peak deactivation clusters, and (3) the maximum absolute responses within the EEG spike field, activation or deactivation. We found that the HRF peak amplitude in deactivation clusters was larger in the HS group than in the FCD when the deactivation occurred in default mode network (DMN) regions. This result suggests that spikes in patients with HS affect the DMN more strongly than those with FCD. However, if we focus on the maximum absolute t-value in the spike field, there is no significant difference between the two groups. The current study indicates that it is not necessary to use different HRF models for EEG–fMRI studies in patients with FCD and HS.
Starting Page	613
Ending Page	619
Page Count	7
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	27
Issue Number	5
e-ISSN	15736792
Language	English
Publisher	Springer US
Publisher Date	2014-04-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hemodynamic response function EEG–fMRI Focal epilepsy Neurosciences Psychiatry Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

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