NDLI: Effect of size on the cellular endocytosis and controlled release of mesoporous silica nanoparticles for intracellular delivery

Content Provider	Springer Nature Link
Author	Gan, Qi Dai, Danwei Yuan, Yuan Qian, Jiangchao Sha, Sha Shi, Jianlin Liu, Changsheng
Copyright Year	2011
Abstract	Due to the unique physicochemical properties and membrane-permeable capacity, mesoporous silica nanoparticles (MSNs) are considered as an ideal carrier for intracellular delivery. Herein, we endeavored to address the size effect of MSNs on the cellular uptake, endosomal escape and controlled release, the key steps for the intracellular delivery. The well-ordered MSNs in the range from 55-nm to 440-nm with similar pore texture were prepared by modified base-catalyzed sol–gel method. With MC3T3-E1 model cell line, the in vitro results indicated that after 12 h cultivation, MSNs within 55 ~ 440 nm could all be internalized into the cells, and further escaped out of the endosomal compartment. The efficiency of the cellular uptake and endosomal escape strongly depended on the particle size, with the best efficiencies from 100-nm MSNs. Furthermore, the MTT results indicated that these MSNs materials were all biocompatible. The controlled release experiments with hydrophobic dexamethasone and hydrophilic vitamin C as models showed that for these small-molecular drugs, the loading amount all mainly determined by the surface area of the MSNs, and the subsequent release of the drug dramatically decreased with the increasing of the particle size. By contrast, the release rate of vitamin C was much quicker than that of the dexamethasone. These findings presented here could provide new means to tailor the size of MSNs and thus to guide the design of MSNs-based intracellular delivery system. Due to the good cell biocompatibility, high cellular uptake and endosomal escape, we conjectured that the 100-nm MSNs are more favorable for the intracellular delivery of drugs in live cells.
Starting Page	259
Ending Page	270
Page Count	12
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	14
Issue Number	2
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2011-11-29
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Size-dependent Mesoporous silica nanoparticles Intracellular delivery Controlled release Nanotechnology Biomedical Engineering Engineering Fluid Dynamics Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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