NDLI: Selectively bonded polymeric glaucoma drainage device for reliable regulation of intraocular pressure

Content Provider	Springer Nature Link
Author	Moon, Seunghwan Im, Seongmin An, Jaeyong Park, Chang Ju Kim, Hwang Gyun Park, Sang Woo Kim, Hyoung Ihl Lee, Jong Hyun
Copyright Year	2011
Abstract	A novel glaucoma drainage device (GDD) using a polymeric micro check valve with no reverse flow is presented for the effective regulation of intraocular pressure (IOP). A significant functional improvement was achieved by reducing the possible incidence of hypotony, as the proposed GDD only drains aqueous humor at a certain cracking pressure or higher. The device consists of three biocompatible polymer layers: a top layer (cover), an intermediate layer (membrane), and a bottom layer (base plate with a cannula). All three layers, made of soft polydimethylsiloxane (PDMS), were bonded together to realize the thin GDDs. The bottom layer was selectively coated with chromium (Cr)/gold (Au) to prevent stiction between the valve seat and the valve orifice so that the device could show enhanced reliability in operation and high yield in production. Two types of polymeric devices were fabricated; one was a glaucoma drainage device for humans (GDDH) and the other was a glaucoma drainage device for animals (GDDA). From subsequent in vitro tests, the cracking pressures were 18.33 ± 0.66 mmHg (mean ± standard deviation) for GDDH and 12.42 mmHg for GDDA, both of which were very close to the corresponding normal IOPs. From in vivo tests of GDDA, the IOP of all implanted devices was properly regulated within the target pressure (10–15 mmHg). The experimental results showed that the proposed polymeric GDD has high potential for use in the treatment of glaucoma disease in terms of its repeatability of the cracking pressure and patients’ relief from post-operative discomfort.
Starting Page	325
Ending Page	335
Page Count	11
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	14
Issue Number	2
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2011-11-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Glaucoma drainage device Intraocular pressure PDMS Check valve MEMS Nanotechnology Biomedical Engineering Engineering Fluid Dynamics Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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