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Oxidative renal tubular injuries induced by aminocarboxylate-type iron (III) coordination compounds as candidate renal carcinogens

Content Provider	Springer Nature Link
Author	Mizu, Ryuichiro Kawabata, Teruyuki Sutoh, Yuichi Nishida, Yuzo Okada, Shigeru
Copyright Year	2006
Abstract	Oxidative renal tubular injuries and carcinogenesis induced by FeIII-nitrilotriacetate (NTA) and FeIII–ethylenediamine-N,N′-diacetate (EDDA) have been reported in rodent kidneys, but the identity of iron coordination structure essential for renal carcinogenesis, remains to be clarified. We compared renal tubular injuries caused by various low molecular weight aminocarboxylate type chelators with injuries due to NTA and EDDA. We found that FeIII-iminodiacetate (IDA), a novel iron-chelator, induced acute tubular injuries and lipid peroxidation to the same extent. We also prepared FeIII-IDA solutions at different pHs, and studied resultant oxidative injuries and physicochemical properties. The use of FeIII-IDA at pH 5.2, 6.2, and 7.2 resulted in renal tubular necrosis and apoptotic cell death, but neither tubular necrosis nor apoptosis was observed at pH 8.2. Spectrophotometric data suggested that FeIII-IDA had the same dimer structure from pH 6.2 to 7.2 as FeIII-NTA; but at a higher pH, iron polymerized and formed clusters. FeIII-IDA was crystallized, and this was confirmed by X-ray analysis and magnetic susceptibility measurements. These data indicated that FeIII-IDA possessed a linear μ-oxo bridged dinuclear iron (III) around neutral pH.
Starting Page	675
Ending Page	683
Page Count	9
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	19
Issue Number	6
e-ISSN	15728773
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-05-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Iron NTA EDTA IDA μ-oxo dimer Physical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

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