NDLI: Reduction of oxidative stress induced vanadium toxicity by complexing with a flavonoid, quercetin: A pragmatic therapeutic approach for diabetes

Content Provider	Springer Nature Link
Author	Shukla, Ruchi Barve, Vivek Padhye, Subhash Bhonde, Ramesh
Copyright Year	2006
Abstract	Vanadium compounds are known to lower blood glucose level in diabetes but are associated with toxicity. In vitro cytotoxicity of VOSO4 and bis(quercetinato) oxovanadium(IV) (BQOV) was examined in CHO cells. Both the agents showed time and dose dependent increase in ROS generation however it was relatively less in BQOV. Moreover, VOSO4 also caused higher necrosis. Hypoglycemic potential of VOSO4 and BQOV was tested in streptozotocin-induced diabetic Balb/c mice. A marked difference was observed in the hypoglycemic action of VOSO4 and BQOV treated mice that lasted only for about 6 h in VOSO4 as against 24 h in BQOV. Comparison of acute toxicity of the compounds in normal Balb/c mice revealed negligible nephrotoxicity of BQOV. Kidney analyses of VOSO4 treated animals’ revealed high ROS generation and tubular necrosis. Similarly serum levels of urea and creatinine were elevated in these animals indicating kidney dysfunction. No such abnormality was observed in BQOV treated animals. Reduced nephrotoxicity of BQOV could be due to increased catalase activity found in the kidney of BQOV treated animals and BQOV’s radical scavenging activity. The data clearly demonstrates immense hypoglycemic activity and reduced toxicity of BQOV thus making the conjugate a suitable candidate for therapeutic utility.
Starting Page	685
Ending Page	693
Page Count	9
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	19
Issue Number	6
e-ISSN	15728773
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-05-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	BQOV nephrotoxicity quercetin ROS generation vanadium Physical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

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