NDLI: Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox

Content Provider	Springer Nature Link
Author	Gaboriau, François Laupen Chassay, Cindy Pasdeloup, Nicole Pierre, Jean Louis Brissot, Pierre Lescoat, Gérard
Copyright Year	2006
Abstract	The antiproliferative effects of the iron chelator O-trensox and the ornithine-decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO) were characterized in the rat hepatoma cell line FAO, the rat liver epithelial cell line (RLEC) and the primary rat hepatocyte cultures stimulated by EGF. We observed that O-trensox and DFMO decreased cell viabilty and DNA replication in the three culture models. The cytostatic effect of O-trensox was correlated to a cytotoxicity, higher than for DFMO, and to a cell cycle arrest in G0/G1 or S phases. Moreover, O-trensox and DFMO decreased the intracellular concentration of spermidine in the three models without changing significantly the spermine level. We concluded that iron, but also polyamine depletion, decrease cell growth. However, the drop in cell proliferation obtained with O-trensox was stronger compared to DFMO effect. Altogether, our data provide insights that, in the three rat liver cell culture models, the cytostatic effect of the iron chelator O-trensox may be the addition of two mechanisms: iron and polyamine depletion.
Starting Page	623
Ending Page	632
Page Count	10
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	19
Issue Number	6
e-ISSN	15728773
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-08-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	cell proliferation iron chelator polyamines rat liver cells Physical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

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