NDLI: A Novel Cationic Ribonuclease with Antimicrobial Activity from Rana dybowskii

Content Provider	Springer Nature Link
Author	Tao, Fengyun Fan, Meiyin Zhao, Wei Lin, Qiang Ma, Runyu
Copyright Year	2011
Abstract	A novel ribonuclease (RNase) A superfamily gene (Rdronc) has been cloned from the frog Rana dybowskii. The deduced amino acid sequence shows that it belongs to the ribonuclease A superfamily, with the highest identity, 73%, to Rana pipiens onconase. Adaptive evolution analysis based on maximum likelihood models of codon substitution has been conducted on 10 members of the Rana RNases of subcluster B. Rapid adaptive evolution and multiple positive selection sites have been detected, which indicates that these genes may be evolving under positive selection pressure. Functional assay demonstrates that the recombinant Rdronc protein possesses antimicrobial activity against Gram-negative Escherichia coli and Pseudomonas aeruginosa and weaker antimicrobial activity against Gram-positive Staphylococcus aureus and yeast Candida albicans. Our findings support the hypothesis that ribonuclease A superfamily members may function in host defense of early-diversified vertebrates.
Starting Page	369
Ending Page	384
Page Count	16
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	49
Issue Number	5-6
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2011-01-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amphibian Ribonuclease Antimicrobial activity Host defense Positive selection Zoology Medical Microbiology Human Genetics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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