NDLI: Positive Selection and Functional Divergence After Melanopsin Gene Duplication

Content Provider	Springer Nature Link
Author	Dong, Changgui Zhang, Junpeng Qiao, Jian He, Guimei
Copyright Year	2011
Abstract	A newly discovered melanopsin gene (Opn4) encodes a member of the opsins, melanopsin. Two melanopsin genes, mammalian-like Opn4m and Xenopus-like Opn4x, have been described in nonmammalian vertebrates, but the underlying evolutionary mechanisms behind the duplication of melanopsin genes remain unclear. We conducted a comprehensive evolutionary analysis within a phylogenetic framework. In our phylogenetic tree, the duplication of Opn4m and Opn4x probably occurred prior to the emergence of vertebrates, and subsequently Opn4x disappeared in the lineages leading to mammalian species. Evolutionary analyses show strong purifying selection during melanopsin evolution. We also provide evidence that Opn4x underwent positive selection after the early gene duplication events. It has been indicated that functional divergence and altered functional constraints occurred between Opn4m and Opn4x duplicates with the identification of positively selected amino acids. Our findings highlight the evolutionary malleability in vertebrate melanopsin genes and provide a genetic basis for comparative studies of functional properties of these two melanopsins.
Starting Page	235
Ending Page	248
Page Count	14
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	50
Issue Number	3-4
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2011-09-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Melanopsin Duplication Positive selection Functional divergence Vertebrates Zoology Human Genetics Biochemistry Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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