NDLI: Regulation of Hemocytes in Drosophila Requires dappled Cytochrome b5

Content Provider	Springer Nature Link
Author	Kleinhesselink, Kurt Conway, Corinna Sholer, David Huang, Irvin Kimbrell, Deborah A.
Copyright Year	2011
Abstract	A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an essential gene that encodes cytochrome b5, a conserved hemoprotein that participates in electron transfer in multiple biochemical reactions and pathways. Viable mutations of dappled cause melanotic nodules and hemocyte misregulation during both hematopoietic waves of development. The sexes are similarly affected, but hemocyte number is different in females and males of both mutants and wild type. Additionally, initial tests show that curcumin enhances the dappled melanotic phenotype and establish screening of endogenous and xenobiotic compounds as a route for analysis of cytochrome b5 function. Overall, dappled provides a tractable genetic model for cytochrome b5, which has been difficult to study in higher organisms.
Starting Page	329
Ending Page	351
Page Count	23
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	49
Issue Number	5-6
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2011-01-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hemocytes dappled Cytochrome b5 Melanotic tumors Granulomas Zoology Medical Microbiology Human Genetics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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Regulation of Hemocytes in Drosophila Requires dappled Cytochrome b5

Regulation of Hemocytes in Drosophila Requires dappled Cytochrome b5

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